The placental theory of hemangioma growth originated from the work developed by North et al (2002) who discovered that the histology and molecular markers unique to placental tissue, namely GLUT1,

An infantile hemangioma (IH) is a type of benign vascular tumor that affects babies. Also, a hypothesis was presented by researchers that maternal placenta Objective—Infantile hemangioma (IH) is a rapidly growing vascular tumor affecting newborns. It is composed of Human retinal and placental pericytes were purchased from Cell and size in response to propranolol has prompted the the av CF WahlgrEn — pressionen i placenta och i infantila hem angiom har static niche theory can elucidate infantile hem angioma spective study of infantile hemangiomas: clini. Hypotesen att infantila hemangiom skulle härröra från placenta är hemangioma (segmentellt i ansiktet/på huvudet), arterial anomalies, av P Jeanty · Citerat av 11 — Ultrasound revealed a single infant in oblique presentation. Another theory suggested that the fetus-in-fetu derived from germ cells from the host Anastomoses that are between dissimilar vessels and occur in the placenta are One case of Meckel diverticulum and another of skin hemangioma have been described. Långön.

Special emphasis will be placed on placental vasculogenesis and the presence and transit of placental progenitor cells during gestation. Background: The unique immunobiology of the placental trophoblast and the increased incidence of hemangiomas in infants born after chorionic villus sampling suggest that an immunologically regulated ectopic focus of trophoblasts could be the cell of origin for proliferative infantile hemangiomas. Objective: To compare tissue from infantile hemangiomas with that of other vascular lesions for the presence of selected placental trophoblast-specific cellular markers. The higher ratio of placental pathologic findings in patients with infantile hemangioma suggests that reduced placental oxygen diffusive conductance contributes to fetal hypoxic stress and that hypoxic/ischemic changes in the placenta could be related to infantile hemangioma development via vascular endothelial growth factor and placental growth factor expression, among others, within the villious vessels and throphoblasts. This concept developed from research showing that molecular markers characteristic of placental tissue, including GLUT1, Lewis Y antigen, merosin, Fc-γ receptor-IIb, indoleamine 2,3-deoxygenase, and type III iodothyronine deiodinase, were also present in IHs. 3, 9 Clinical evidence for this theory is suggested by those studies showing an increased incidence of IH in association with chorionic villus sampling, placenta previa, and preeclampsia. 24, 30, 31 Shared expression of distinct endothelial markers in hemangioma and placental tissues raises a possibility that infantile hemangioma is originated from placental trophoblast. Moreover, the findings of a very high similarity between the transcriptomes of placenta and hemangioma provide strong support for this theory.

Barnés CMChristison-Lagay EAFolkman J The placenta theory and the origin of infantile hemangioma. Lymphat Res Biol 2007;5 (4) 245- 255 PubMed Google Scholar Crossref 17.

However, infantile hemangiomas most likely arise from hematopoietic progenitor cells (from placenta or stem cell) in the appropriate milieu of genetic alterations and cytokines. Abnormal levels of matrix metalloproteinases (MMP-9) and proangiogenic factors (VEGF, b-FGF, and TGF-beta 1) play a role in hemangioma pathogenesis [ 6 ].

Jun 12, 2014 Different theories, including the heredity and gene mutation theory, the placental chorionic cell ectopia theory, the endothelial progenitor cell or May 1, 2006 For many years, all vascular anomalies were called hemangiomas. At present, there is no cohesive theory of the etiology of infantile hemangiomas, of hemangiomas involves cells of origin derived from the placenta th Apr 26, 2016 The terms 'infantile haemangioma' or 'haemangioma of infancy' are typically Folkman J. The placenta theory and the origin of infantile hemangioma. Infantile hemangiomas: speculation on placental tr Dec 24, 2012 Fallon Friedlander.

In the past, it was believed that a mother’s visual impressions or behavior during pregnancy caused the growth of infantile hemangioma in Barnés CMChristison-Lagay EAFolkman J The placenta theory and the origin of infantile hemangioma. Lymphat Res Biol 2007;5 (4) 245- 255 PubMed Google Scholar Crossref 17. Infantile (juvenile) capillary hemangiomas are vascular neoplasms which can appear quite infiltrative histologically and are characterized by cords of cells with areas of marked cellularity. While vessels can be distinguished in most cases, there are many cells which do not appear to be endothelial in origin. The placenta is suggested as the site of humoral factors that prepare a niche similar to the function of malignant tumor cells.
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Abnormal levels of matrix metalloproteinases (MMP-9) and proangiogenic factors (VEGF, b-FGF, and TGF-beta 1) play a role in hemangioma pathogenesis [ 6 ]. The placenta is suggested as the site of humoral factors that prepare a niche similar to the function of malignant tumor cells.
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Barnés CMChristison-Lagay EAFolkman J The placenta theory and the origin of infantile hemangioma. Lymphat Res Biol 2007;5 (4) 245- 255 PubMed Google Scholar Crossref 17.

Background: The unique immunobiology of the placental trophoblast and the increased incidence of hemangiomas in infants born after chorionic villus sampling suggest that an immunologically regulated ectopic focus of trophoblasts could be the cell of origin for proliferative infantile hemangiomas. Objective: To compare tissue from infantile hemangiomas with that of other vascular lesions for the presence of selected placental trophoblast-specific cellular markers. The higher ratio of placental pathologic findings in patients with infantile hemangioma suggests that reduced placental oxygen diffusive conductance contributes to fetal hypoxic stress and that hypoxic/ischemic changes in the placenta could be related to infantile hemangioma development via vascular endothelial growth factor and placental growth factor expression, among others, within the villious vessels and throphoblasts. This concept developed from research showing that molecular markers characteristic of placental tissue, including GLUT1, Lewis Y antigen, merosin, Fc-γ receptor-IIb, indoleamine 2,3-deoxygenase, and type III iodothyronine deiodinase, were also present in IHs. 3, 9 Clinical evidence for this theory is suggested by those studies showing an increased incidence of IH in association with chorionic villus sampling, placenta previa, and preeclampsia. 24, 30, 31 Shared expression of distinct endothelial markers in hemangioma and placental tissues raises a possibility that infantile hemangioma is originated from placental trophoblast. Moreover, the findings of a very high similarity between the transcriptomes of placenta and hemangioma provide strong support for this theory. The higher ratio of placental pathologic findings in patients with infantile hemangioma suggests that reduced placental oxygen diffusive conductance contributes to fetal hypoxic stress and that hypoxic/ ischemic changes in the placenta could be related to infantile hemangioma development via vascular endothelial growth factor and placental growth factor expression, among others, within the villious vessels and thropho- blasts.

The placenta releases angiostatic factors (sFLT1), but after birth these inhibitory factors are wasted, which allows the development of the infantile hemangioma by endothelial cell proliferation

Although benign, infants with IH can experience complications including ulceration, visual and airway impairment, and residual scarring and disfigurement. It is often challenging for clinicians to predict which tumors are in need of systemic treatment.

This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. Special emphasis will be placed on placental This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. Special emphasis will be placed on placental vasculogenesis and the presence and transit of placental progenitor cells during gestation.